By Dr. Joni Grace, BHMS, PGDCR, Strategic Case Management Consultant, Jhpiego (Johns Hopkins Program for International Education in Gynecology and Obstetrics)

Sepsis is a serious and potentially life-threatening medical condition characterized by a dysregulated systemic response to infection. It is a major global health concern, accounting for a significant number of hospital admissions, prolonged stays, and mortality rates worldwide.

Hospital-acquired sepsis occurs when an infection develops after admission to a healthcare facility, such as a hospital or long-term care facility. It typically arises due to the introduction of pathogens into the patient’s bloodstream through invasive procedures, contaminated medical devices, surgical sites, or poor hygiene practices. Common causative organisms include Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Candida species.

The global burden of sepsis is difficult to ascertain, although a recent scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20% of all global deaths. In 2017, almost half of all global sepsis cases occurred among children, with an estimated 20 million cases and 2.9 million global deaths in children under five years of age. 

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