The guidelines for preventing VTE after total joint arthroplasty (such as, knee and hip replacement) by the Academy of Orthopaedic Surgeons and American College of Chest Physicians are unanimous – both pharmacological and mechanical prophylaxis are needed.

The AAOS recommends the use of pharmacological and/or mechanical compression devices for both total hip arthroplasty (THA) and total knee replacement (TKA) patients who are not at an elevated risk for VTE or bleeding, as well as for patients with a known bleeding disorder and/or active liver disease.
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